Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and protein dimerization activity. Predicted to act upstream of or within several processes, including kidney development; lung development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in mesoderm. Human ortholog(s) of this gene implicated in coronary artery disease and ventricular septal defect. Orthologous to human TCF21 (transcription factor 21).