Version: 8.0.0Date: Tue Jan 28 2025
Gene
tgfbr2
- Species
- Xenopus tropicalis
- Symbol
- tgfbr2
- Name
- transforming growth factor beta receptor 2
- Synonyms
- aat3
- faa3
- Biotype
- gene
- Automated Description
- Predicted to enable several functions, including activin binding activity; transforming growth factor beta binding activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in several processes, including activin receptor signaling pathway; cellular response to growth factor stimulus; and heart development. Predicted to act upstream of or within apoptotic process; cell differentiation; and cell surface receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane raft. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in anatomical system; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2).
- XBXT Description
- serine/threonine kinasehttps://www.xenbase.org/gene/showgene.do?method=display&geneId=485605
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- Not Available
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr06:75036908...75056562 - (19.65 kb)
- Assembly version
- XT9.1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
- None
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.