Predicted to enable estrogen response element binding activity and nuclear receptor activity. Predicted to be involved in estrogen receptor signaling pathway and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to estradiol stimulus and regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2).