Gene

edn1

Species
Xenopus tropicalis
Symbol
edn1
Name
endothelin 1
Synonyms
  • edn1
  • edn1-a
Biotype
gene
Automated Description
Predicted to enable endothelin A receptor binding activity; endothelin B receptor binding activity; and hormone activity. Predicted to be involved in several processes, including positive regulation of smooth muscle contraction; regulation of systemic arterial blood pressure by endothelin; and vein smooth muscle contraction. Predicted to act upstream of or within regulation of vasoconstriction and vasoconstriction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in musculoskeletal system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1).
XBXT Description
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
XT9.1
Viewer Help
85.351M85.352M85.353M85.354M85.355M85.356M85.357M85.358M

Sequence Details

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Expression

Primary Sources
Other Sources
None
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions