Predicted to enable endothelin A receptor binding activity; endothelin B receptor binding activity; and hormone activity. Predicted to be involved in several processes, including positive regulation of smooth muscle contraction; regulation of systemic arterial blood pressure by endothelin; and vein smooth muscle contraction. Predicted to act upstream of or within regulation of vasoconstriction and vasoconstriction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in musculoskeletal system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1).