Predicted to enable 1-phosphatidylinositol-3-kinase activity and protein serine/threonine kinase activity. Predicted to act upstream of or within mitotic spindle assembly checkpoint signaling and response to ionizing radiation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase).