Predicted to enable K48-linked deubiquitinase activity. Predicted to act upstream of or within protein K48-linked deubiquitination and proteolysis. Human ortholog(s) of this gene implicated in congenital secretory chloride diarrhea 1 and diarrhea. Orthologous to several human genes including MINDY4 (MINDY lysine 48 deubiquitinase 4).