Predicted to enable chromatin binding activity. Predicted to act upstream of or within mitochondrial DNA replication. Part of gamma DNA polymerase complex. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. Orthologous to human POLG (DNA polymerase gamma, catalytic subunit).
XBXL Description
mitochondrial DNA polymerase gamma, catalytic subunit