Predicted to enable histone H3K36 methyltransferase activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within chromatin organization; methylation; and regulation of DNA-templated transcription. Predicted to be active in chromosome and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; clear cell renal cell carcinoma; gastrointestinal system cancer (multiple); lung disease (multiple); and malignant mesothelioma (multiple). Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase).