Predicted to enable ephrin receptor binding activity. Acts upstream of or within Kupffer's vesicle development and blood vessel development. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse and presynaptic membrane. Is expressed in margin and segmental plate. Human ortholog(s) of this gene implicated in colon carcinoma; colorectal carcinoma; and esophagus squamous cell carcinoma. Orthologous to human EFNB2 (ephrin B2).