Gene

caspb

Species
Danio rerio
Symbol
caspb
Name
caspase b
Synonyms
  • casp19a
  • caspy2
Biotype
protein coding gene
Automated Description
Enables aspartic-type peptidase activity; cysteine-type endopeptidase activity; and lipopolysaccharide binding activity. Involved in several processes, including defense response to bacterium; positive regulation of pyroptotic inflammatory response; and self proteolysis. Acts upstream of or within positive regulation of apoptotic process and pyroptotic inflammatory response. Part of NLRP1 inflammasome complex. Is expressed in several structures, including digestive system; heart; immune system; integument; and muscle. Orthologous to human CASP4 (caspase 4).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10454
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
58.052M58.054M58.056M58.058M58.060M58.062M58.064M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions