Gene

plg

Species
Danio rerio
Symbol
plg
Name
plasminogen
Synonyms
  • wu:fb70e09
Biotype
protein coding gene
Automated Description
Predicted to enable endopeptidase activity and signaling receptor binding activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within hemostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; conjunctivitis; hereditary angioedema; myocardial infarction; and plasminogen deficiency type I. Orthologous to several human genes including PLG (plasminogen).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44106
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensPLG10 of 10YesYes  
Homo sapiensLPA3 of 10NoYes  
Mus musculusPlg9 of 10YesYes  
Rattus norvegicusPlg9 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
mst1182850363 of 8  
hgfa281449353 of 8  
plat372538282 of 8  
zgc:100868425356402 of 8  
si:dkeyp-93a5.3527050362 of 8  
ovch1623756412 of 8  
zgc:123217724454362 of 8  
pik3ip1814044342 of 8  
hgfb92 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
statoacoustic (VIII) ganglion has normal numbers of parts of type neuron, normal
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCz11
Viewer Help
42.690M42.692M42.694M42.696M42.698M42.700M42.702M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
sa44949allele
mi4011allele
sa39304allele with one associated variant
point mutation
  • splice donor variant
sa39303allele with one associated variant
point mutation
  • stop gained
sa16064allele with one associated variant
point mutation
  • stop gained
sa37133allele with one associated variant
point mutation
  • stop gained
sa37132allele with one associated variant
point mutation
  • splice donor variant
sa16767allele with one associated variant
point mutation
  • stop gained
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
pgk1x40/x40; zc7Tg + MO1-plg + MO4-tp53
has condition:
standard conditions
  • statoacoustic (VIII) ganglion has fewer parts of type neuron, abnormal
ZFIN
pgk1x55/x55; zc7Tg + MO1-plg + MO4-tp53
has condition:
standard conditions
  • statoacoustic (VIII) ganglion has fewer parts of type neuron, abnormal
ZFIN
pgk1x55/x55; zc7Tg + MO2-plg + MO4-tp53
has condition:
standard conditions
  • statoacoustic (VIII) ganglion has fewer parts of type neuron, abnormal
ZFIN
zc7Tg + MO1-plg + MO4-tp53
has condition:
standard conditions
  • statoacoustic (VIII) ganglion has normal numbers of parts of type neuron, normal
ZFIN
zc7Tg + MO2-plg + MO4-tp53
has condition:
standard conditions
  • statoacoustic (VIII) ganglion has normal numbers of parts of type neuron, normal
ZFIN
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Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
42.690M42.692M42.694M42.696M42.698M42.700M42.702M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available