Gene

ptpn11a

Species
Danio rerio
Symbol
ptpn11a
Name
protein tyrosine phosphatase non-receptor type 11a
Synonyms
  • fa14b09
  • ptpn11
Biotype
protein coding gene
Automated Description
Enables protein tyrosine phosphatase activity. Acts upstream of or within several processes, including embryonic morphogenesis; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and neuromast hair cell development. Predicted to be active in cytoplasm. Is expressed in several structures, including blastoderm; blastomere; gill; immune system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19134
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
3.430M3.432M3.434M3.436M3.438M3.440M3.442M3.444M3.446M3.448M3.450M3.452M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions