Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hypothalamus development. Predicted to be active in nucleus. Is expressed in caudal tuberculum; diencephalon; forebrain; hypothalamus; and intermediate hypothalamus. Orthologous to human NKX2-4 (NK2 homeobox 4).