Gene

nucb2a

Species
Danio rerio
Symbol
nucb2a
Name
nucleobindin 2a
Synonyms
  • cb638
  • nucb2
Biotype
protein coding gene
Automated Description
Predicted to enable calcium ion binding activity. Acts upstream of or within response to food. Predicted to be located in Golgi apparatus. Predicted to be active in endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including axial mesoderm; cardiovascular system; digestive system; gonad; and pectoral fin. Orthologous to human NUCB2 (nucleobindin 2).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19237
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensNUCB29 of 10YesYes  
Mus musculusNucb29 of 10YesYes  
Rattus norvegicusNucb28 of 9YesYes   
Xenopus tropicalisnucb23 of 9YesYes   
Drosophila melanogasterNUCB18 of 10YesYes  
Caenorhabditis elegansnucb-19 of 9YesYes   
Saccharomyces cerevisiaeSSP1202 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
nucb2b142688788 of 8  
nucb1248367527 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
nucb2a (Dre)
NUCB2 (Hsa)
Nucb2 (Mmu)
Nucb2 (Rno)
nucb2 (Xtr)
NUCB1 (Dme)
nucb-1 (Cel)
SSP120 (Sce)
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Homo sapiensNUCB2
is marker fortype 2 diabetes mellitus
  • IEP
    Rattus norvegicusNucb2
    is marker foralcohol dependence
    • IEP
      Rattus norvegicusNucb2
      is marker forobesity
      • IEP
        Rattus norvegicusNucb2
        is marker fortype 2 diabetes mellitus
        • IEP
          Showing 1 - 4 of 4 rows
          per page

          Alleles and Variants

          Genome location
          Assembly version
          GRCz11
          Viewer Help
          27.026M27.028M27.030M27.032M27.034M27.036M27.038Msa16703nucb2anucb2a-201nucb2a-202nucb2a-203nucb2a-204
          Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
          Allele/Variant Symbol
          Allele Synonyms
          Category
          Variant
          Variant type
          Molecular consequence
          Has Disease Annotations
          Has Phenotype Annotations
          sa16703allele with one associated variant
          point mutation
          • splice donor variant
          Showing 1 - 1 of 1 rows
          per page

          Transgenic Alleles

          No data available

          Models

          No data available

          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCz11
          Viewer Help
          27.026M27.028M27.030M27.032M27.034M27.036M27.038Mnucb2a-201 (nucb2a)nucb2a-202 (nucb2a)nucb2a-203 (nucb2a)nucb2a-204 (nucb2a)

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
          nucb2a (Dre)
          Nucb2 (Mmu)
          Nucb2 (Rno)
          NUCB1 (Dme)
          nucb-1 (Cel)
          SSP120 (Sce)
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          No data available

          Genetic Interactions

          No data available