Acts upstream of or within negative regulation of cellular response to hypoxia. Predicted to be active in cytoplasm. Is expressed in several structures, including caudal vein plexus; corpuscles of Stannius; integument; pleuroperitoneal region; and visual system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to human NDRG1 (N-myc downstream regulated 1).