Version: 8.0.0
Date: Tue Jan 28 2025
tardbpa
Danio rerioZFIN:ZDB-GENE-031030-1
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

tardbpa

Species
Danio rerio
Symbol
tardbpa
Name
TAR DNA binding protein a
Synonyms
  • tardbp
  • tardbpl
Biotype
protein coding gene
Automated Description
Predicted to enable RNA binding activity. Acts upstream of or within several processes, including axon extension; neuromuscular junction development; and skeletal muscle tissue development. Predicted to be located in mitochondrion and nucleus. Predicted to be active in chromatin and nucleoplasm. Is expressed in brain and fin. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44166
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensTARDBP9 of 10YesNo☑ ☐☑☑☑☑☑☑☑ ☑
Mus musculusTardbp9 of 10YesNo☑ ☐☑☑☑☑☑☑☑ ☑
Rattus norvegicusTardbp8 of 9YesNo☑ ☐☑☑☑☑☑☑☑  
Xenopus tropicalistardbp8 of 9YesNo☑ ☐☑☑☑☑☑☑☑  
Drosophila melanogastercocoon9 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☐
Drosophila melanogasterTBPH8 of 10NoYes☑ ☑☑☐☑☑☑☑☑ ☐
Caenorhabditis eleganstdp-19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
tardbpb141488817 of 8☑ ☑☐☑☑☑☑☑ 
hnrnpd233844282 of 8☐ ☐☐☐☐☑☑☐ 
hnrnpdl331743302 of 8☐ ☐☐☐☐☑☑☐ 
hnrnpabb431945272 of 8☐ ☐☐☐☐☑☑☐ 
hnrnpaba531341272 of 8☐ ☐☐☐☐☑☑☐ 
pabpc4637835202 of 8☑ ☐☐☐☐☐☑☐ 
rbm14b733038242 of 8☑ ☐☐☐☐☐☑☐ 
rbm14a830638252 of 8☑ ☐☐☐☐☐☑☐ 
puf60b936134182 of 8☑ ☐☐☐☐☐☑☐ 
puf60a1031837192 of 8☑ ☐☐☐☐☐☑☐ 
rbm341118141232 of 8☑ ☐☐☐☐☐☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
axon extension process quality, normal
brain tardbpa expression absent, abnormal
eye size, normal
fast muscle cell mini excitatory postsynaptic potential frequency, normal
fast muscle cell neuromuscular synaptic transmission process quality, normal
heart morphology, normal
motor neuron axon length, normal
musculoskeletal movement occurrence, normal
myotome neuromuscular junction development decreased occurrence, abnormal
neuromuscular junction development process quality, abnormal
Showing 1 - 10 of 17 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
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    Alleles and Variants

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    mde159allele with one associated variantYes
    nkz4
    • n94
    		allele with one associated variant
    deletion
    • frameshift variant
    udm104allele with one associated variant
    deletion
    • frameshift variant
    		Yes
    mde114allele with one associated variant
    deletion
    • frameshift variant
    		Yes
    mde222allele with one associated variant
    deletion
    • frameshift variant
    		Yes
    sa39415allele with one associated variant
    point mutation
    • stop gained
    Showing 1 - 6 of 6 rows
    per page
    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    tardbpamde114/mde114 (AB)
    has condition:
    standard conditions
    • axon extension process quality, normal
    • motor neuron axon length, normal
    		ZFIN
    tardbpamde114/mde114; tardbpbmde150/mde150 (AB)
    has condition:
    standard conditions
    • blood circulation disrupted, abnormal
    • motor neuron axon decreased length, abnormal
    		ZFIN
    tardbpamde114/mde114; tardbpbmde150/mde150; s896Tg (AB)
    has condition:
    standard conditions
    • cranial vasculature irregular spatial pattern, abnormal
    • intersegmental vessel decreased functionality, abnormal
    		ZFIN
    tardbpamde114/mde114; tardbpbmde198/mde198 (AB)
    has condition:
    standard conditions
    • blood circulation disrupted, abnormal
    • motor neuron axon decreased length, abnormal
    		ZFIN
    tardbpamde114/mde114; tardbpbmde198/mde198; s896Tg (AB)
    has condition:
    standard conditions
    • cranial vasculature irregular spatial pattern, abnormal
    • intersegmental vessel decreased functionality, abnormal
    		ZFIN
    tardbpamde114/mde114; tardbpbmde201/mde201 (AB)
    has condition:
    standard conditions
    • blood circulation disrupted, abnormal
    • motor neuron axon decreased length, abnormal
    		ZFIN
    tardbpamde114/mde114; tardbpbmde201/mde201; s896Tg (AB)
    has condition:
    standard conditions
    • cranial vasculature irregular spatial pattern, abnormal
    • intersegmental vessel decreased functionality, abnormal
    		ZFIN
    tardbpamde114/mde114; tardbpbmde897/mde897 (AB)
    has condition:
    standard conditions
    • blood circulation disrupted, abnormal
    • motor neuron axon decreased length, abnormal
    		ZFIN
    tardbpamde114/mde114; tardbpbmde897/mde897; s896Tg (AB)
    has condition:
    standard conditions
    • cranial vasculature irregular spatial pattern, abnormal
    • intersegmental vessel decreased functionality, abnormal
    		ZFIN
    tardbpamde114/mde114; tardbpbmde909/mde909 (AB)
    has condition:
    standard conditions
    • blood circulation disrupted, abnormal
    • motor neuron axon decreased length, abnormal
    		ZFIN
    Showing 1 - 10 of 53 rows
    per page

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available