Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in JNK cascade. Predicted to act upstream of or within protein autophosphorylation. Predicted to be active in cytoplasm. Is expressed in central nervous system; cranial ganglion; neural tube; neurons; and retina. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12).