Version: 8.0.0Date: Tue Jan 28 2025
Gene
pias4a
- Species
- Danio rerio
- Symbol
- pias4a
- Name
- protein inhibitor of activated STAT, 4a
- Synonyms
- pias4
- piasy
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable SUMO ligase activity and transcription coregulator activity. Acts upstream of or within negative regulation of type I interferon production and negative regulation of type I interferon-mediated signaling pathway. Located in nucleus. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human PIAS4 (protein inhibitor of activated STAT 4).
- ZFIN Description
- Not Available
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10782
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | PIAS4 | 10 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☑ |
| Mus musculus | Pias4 | 10 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☑ |
| Rattus norvegicus | Pias4 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Xenopus tropicalis | pias4 | 8 of 9 | Yes | Yes | ☐ ☑☑☑☑☑☑☑☑ |
| Drosophila melanogaster | Su(var)2-10 | 5 of 10 | Yes | No | ☑ ☑☐☐☑☐☑☑☐ ☐ |
| Caenorhabditis elegans | gei-17 | 6 of 9 | Yes | Yes | ☐ ☑☑☐☑☑☐☑☑ |
| Saccharomyces cerevisiae | NFI1 | 8 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☑☑☑ |
| Saccharomyces cerevisiae | SIZ1 | 8 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☑☑☑ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Paralogy
| Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
|---|---|---|---|---|---|---|
| pias1a | 1 | 527 | 55 | 43 | 7 of 8 | ☑ ☑☐☑☑☑☑☑ |
| pias4b | 2 | 470 | 62 | 46 | 7 of 8 | ☑ ☑☐☑☑☑☑☑ |
| pias1b | 3 | 525 | 55 | 41 | 7 of 8 | ☑ ☑☐☑☑☑☑☑ |
| pias2 | 4 | 538 | 52 | 38 | 7 of 8 | ☑ ☑☐☑☑☑☑☑ |
| zmiz1a | 5 | 475 | 35 | 25 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| zmiz2 | 6 | 486 | 37 | 25 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| zmiz1b | 7 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
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Alleles and Variants
- Genome location
- Chr22:20406410...20419660 (13.25 kb)
- Assembly version
- GRCz11
- Viewer Help
Data currently unavailable; sequence viewer under construction
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Sequence Feature Viewer
- Genome location
- Chr22:20406410...20419660 (13.25 kb)
- Assembly version
- GRCz11
- Viewer Help
Data currently unavailable; sequence viewer under construction