Gene

fitm2

Species
Danio rerio
Symbol
fitm2
Name
fat storage inducing transmembrane protein 2
Synonyms
  • c20orf142
  • fit2
Biotype
protein coding gene
Automated Description
Predicted to enable coenzyme A diphosphatase activity; diacylglycerol binding activity; and triglyceride binding activity. Acts upstream of or within several processes, including glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adaxial cell and slow muscle cell. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to human FITM2 (fat storage inducing transmembrane protein 2).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23129
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensFITM210 of 10YesYes  
Mus musculusFitm210 of 10YesYes  
Rattus norvegicusFitm29 of 9YesYes   
Xenopus tropicalisfitm29 of 9YesYes   
Drosophila melanogasterFitm7 of 10YesYes  
Caenorhabditis elegansfitm-28 of 9YesYes   
Saccharomyces cerevisiaeYFT24 of 9YesYes   
Saccharomyces cerevisiaeSCS34 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
fitm1l125247274 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
glucose homeostasis disrupted, abnormal
lipid storage disrupted, abnormal
pancreatic B cell decreased amount, abnormal
pancreatic B cell decreased area, abnormal
Showing 1 - 4 of 4 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
jh1Tg; jh2Tg + MO3-fitm2
has condition:
standard conditions
  • glucose homeostasis disrupted, abnormal
  • pancreatic B cell decreased amount, abnormal
ZFIN
jh1Tg; jh2Tg + MO3-fitm2
has condition:
chemical treatment by environment glucose
  • glucose homeostasis disrupted, abnormal
  • pancreatic B cell increased amount, abnormal
ZFIN
jh4Tg + MO3-fitm2
has condition:
chemical ablation pancreatic B cellchemical treatment by environment metronidazole
  • pancreatic B cell regeneration decreased rate, abnormal
ZFIN
WT + MO1-fitm2
has condition:
standard conditions
  • lipid storage disrupted, abnormal
ZFIN
WT + MO2-fitm2
has condition:
standard conditions
  • lipid storage disrupted, abnormal
ZFIN
Showing 1 - 5 of 5 rows
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Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
25.7964M25.7966M25.7968M25.7970M25.7972M25.7974M25.7976M25.7978M25.7980M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available