Gene

tfpi2

Species
Danio rerio
Symbol
tfpi2
Name
tissue factor pathway inhibitor 2
Synonyms
  • si:ch211-262k23.2
Biotype
protein coding gene
Automated Description
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including heart development; regulation of hemopoiesis; and sarcomere organization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; eye; heart; liver; and ovary. Human ortholog(s) of this gene implicated in acute myeloid leukemia and retinal degeneration. Orthologous to human TFPI2 (tissue factor pathway inhibitor 2).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10083
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
tfpia122948326 of 8  
spint2225145284 of 8  
si:dkeyp-73b11.8317545304 of 8  
tfpil414049364 of 8  
lrp11525735232 of 8  
spint1a621439252 of 8  
ambp716848322 of 8  
wfikkn2a817045322 of 8  
wfikkn1915450322 of 8  
spint1b1018438272 of 8  
wfikkn2b1115445282 of 8  
kiaa0319l1213835222 of 8  
si:dkey-117n7.5135360452 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
atrioventricular canal malformed, abnormal
atrium dilated, abnormal
cardiac muscle cell cardiac myofibril decreased amount, abnormal
cardiac muscle cell sarcomere disorganized, abnormal
cardiac muscle cell sarcomere organization disrupted, abnormal
cardiac muscle cell Z disc disorganized, abnormal
cardiac ventricle decreased size, abnormal
fourth ventricle decreased size, abnormal
glial cell (sensu Vertebrata) decreased amount, abnormal
head decreased size, abnormal
Showing 1 - 10 of 25 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
AB + MO1-tfpi2
has condition:
standard conditions
  • fourth ventricle decreased size, abnormal
  • midbrain hindbrain boundary malformed, abnormal
ZFIN
AB + MO1-tfpi2 + MO4-tp53
has condition:
standard conditions
  • fourth ventricle decreased size, abnormal
  • midbrain hindbrain boundary malformed, abnormal
ZFIN
AB + MO2-tfpi2
has condition:
standard conditions
  • midbrain hindbrain boundary malformed, abnormal
  • whole organism decreased pigmentation, abnormal
ZFIN
mi2001Tg + MO1-tfpi2
has condition:
standard conditions
  • glial cell (sensu Vertebrata) decreased amount, abnormal
ZFIN
WT + MO1-tfpi2
has condition:
standard conditions
  • atrioventricular canal malformed, abnormal
  • atrium dilated, abnormal
ZFIN
WT + MO1-tfpi2 + MO2-tfpi2
has condition:
standard conditions
  • heart development disrupted, abnormal
  • heart malformed, abnormal
ZFIN
WT + MO2-tfpi2
has condition:
standard conditions
  • head decreased size, abnormal
  • heart contraction decreased rate, abnormal
ZFIN
knu3Tg + MO1-tfpi2ZFIN
Showing 1 - 8 of 8 rows
per page

Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
40.849M40.850M40.851M40.852M40.853M40.854M40.855M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available