Version: 8.0.0
Date: Tue Jan 28 2025
kdm4c
Danio rerioZFIN:ZDB-GENE-070209-38
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

kdm4c

Species
Danio rerio
Symbol
kdm4c
Name
lysine (K)-specific demethylase 4C
Synonyms
  • jmjd2c
  • wu:fd55d07
Biotype
protein coding gene
Automated Description
Predicted to enable histone H3K36 demethylase activity and histone H3K9 demethylase activity. Acts upstream of or within blood vessel morphogenesis; pronephric glomerulus development; and pronephric proximal tubule morphogenesis. Predicted to be active in chromatin and nucleus. Is expressed in female organism. Human ortholog(s) of this gene implicated in autistic disorder; breast cancer; carcinoma (multiple); head and neck cancer; and withdrawal disorder. Orthologous to human KDM4C (lysine demethylase 4C).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10694
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensKDM4C6 of 10YesYes☐ ☐☐☑☑☐☑☑☑ ☑
Mus musculusKdm4c8 of 10YesYes☐ ☐☑☑☑☑☑☑☑ ☑
Rattus norvegicusKdm4d2 of 9YesYes☑ ☐☐☐☐☐☑☐☐  
Xenopus tropicaliskdm4c2 of 9YesYes☐ ☐☐☐☑☐☑☐☐  
Drosophila melanogasterKdm4A4 of 10YesNo☐ ☐☐☐☑☑☐☑☑ ☐
Caenorhabditis elegansjmjd-26 of 9YesNo☐ ☑☑☐☑☑☐☑☑  
Saccharomyces cerevisiaeRPH16 of 9YesYes☑ ☐☐☐☑☑☑☑☑  
Saccharomyces cerevisiaeGIS15 of 9NoYes☐ ☐☐☐☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
kdm4aa1202846337 of 8☑ ☑☐☑☑☑☑☑ 
kdm4ab2145951397 of 8☑ ☑☐☑☑☑☑☑ 
kdm4b3146447377 of 8☑ ☑☐☑☑☑☑☑ 
kdm5a4150034203 of 8☑ ☐☐☐☐☑☑☐ 
kdm5ba5130735203 of 8☑ ☐☐☐☐☑☑☐ 
kdm5c6125736223 of 8☑ ☐☐☐☐☑☑☐ 
kdm5bb7132632203 of 8☑ ☐☐☐☐☑☑☐ 
jarid2a857537213 of 8☑ ☐☐☐☐☑☑☐ 
jarid2b940138223 of 8☑ ☐☐☐☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
pronephric glomerulus swollen, abnormal
pronephric proximal convoluted tubule distended, abnormal
whole organism semi-viable, abnormal
whole organism viability, abnormal
Showing 1 - 4 of 4 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
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    Alleles and Variants

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    zko421aallele
    sa1889allele
    sa24842allele with one associated variant
    point mutation
    • stop gained
    sa19486allele with one associated variant
    point mutation
    • stop gained
    sa12098allele with one associated variant
    point mutation
    • stop gained
    sa39604allele with one associated variant
    point mutation
    • stop gained
    Showing 1 - 6 of 6 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    csf1ratm236b/tm236b; mpv17b18/b18; slc45a2b4/b4; y1Tg + MO1-kdm4c
    has condition:
    standard conditions
    • angiogenesis disrupted, abnormal
    • blood vessel decreased area, abnormal
    		ZFIN
    li1Tg + MO2-kdm4c
    has condition:
    standard conditions
    • pronephric glomerulus swollen, abnormal
    • pronephric proximal convoluted tubule distended, abnormal
    		ZFIN
    Showing 1 - 2 of 2 rows
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    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available