Gene

lepr

Species
Danio rerio
Symbol
lepr
Name
leptin receptor
Synonyms
  • obr
Biotype
protein coding gene
Automated Description
Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in leptin-mediated signaling pathway and regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including oocyte maturation; ovulation; and type B pancreatic cell development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including digestive system; musculature system; nervous system; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23036
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
31.185M31.190M31.195M31.200M31.205M31.210M31.215M31.220M31.225M31.230M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions