Gene

slc16a2

Species
Danio rerio
Symbol
slc16a2
Name
solute carrier family 16 member 2
Synonyms
  • MCT8
Biotype
protein coding gene
Automated Description
Enables thyroid hormone binding activity and thyroid hormone transmembrane transporter activity. Acts upstream of or within several processes, including nervous system development; optomotor response; and thyroid gland development. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; digestive system; eye; and hindbrain neural keel. Used to study Allan-Herndon-Dudley syndrome. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome and intellectual disability. Orthologous to human SLC16A2 (solute carrier family 16 member 2).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSLC16A21 of 10YesYes  
Mus musculusSlc16a21 of 10YesYes  

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
apoptotic process increased occurrence, abnormal
brain mbpa expression decreased amount, abnormal
brain mpz expression decreased amount, abnormal
brain olig2 expression increased amount, abnormal
brain pax6a expression decreased amount, abnormal
brain plp1b expression decreased amount, abnormal
brain sox10 expression increased amount, abnormal
brain wls expression increased amount, abnormal
brain apoptotic process increased process quality, abnormal
brain deformed, abnormal
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Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Danio rerioslc16a2
is implicated inAllan-Herndon-Dudley syndrome
  • TAS
  • IC
    Homo sapiensSLC16A2
    is implicated inAllan-Herndon-Dudley syndrome
    • IAGP
      Homo sapiensSLC16A2
      is implicated inintellectual disability
      • IAGP
        Mus musculusSlc16a2
        is implicated inAllan-Herndon-Dudley syndrome
        • TAS
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          Alleles and Variants

          Allele/Variant Symbol
          Allele Synonyms
          Category
          Variant
          Variant type
          Molecular consequence
          Has Disease Annotations
          Has Phenotype Annotations
          ihb567allele
          Yes
          alv1allele
          biu19allele
          Yes
          ihb566allele
          Yes
          biu4allele with one associated variantYesYes
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          Transgenic Alleles

          Species
          (carrying the transgene)
          Allele symbol
          Transgenic construct
          Expressed components
          Knock-down targets
          Regulatory regions
          Has Disease Annotations
          Has Phenotype Annotations
          Danio reriobiu10Tg
          Showing 1 - 1 of 1 rows
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
          slc16a2biu4/biu4
          has condition:
          standard conditions
          • Rohon-Beard neuron collateral sprouting decreased process quality, abnormal
          • Rohon-Beard neuron has fewer parts of type Rohon-Beard neuron dendritic filopodium, abnormal
          ZFIN
          slc16a2biu4/biu4; ck1Tg
          has condition:
          standard conditions
          • brain oligodendrocyte decreased amount, abnormal
          • hindbrain oligodendrocyte decreased amount, abnormal
          ZFIN
          WT + MO3-slc16a2
          has condition:
          standard conditions
          • brain apoptotic process increased process quality, abnormal
          • brain development process quality, abnormal
          ZFIN
          AB + MO4-tp53 + MO5-slc16a2
          has condition:
          standard conditions
          • apoptotic process increased occurrence, abnormal
          • brain development disrupted, abnormal
          ZFIN
          AB + MO5-slc16a2
          has condition:
          standard conditions
          • apoptotic process increased occurrence, abnormal
          • brain pax6a expression decreased amount, abnormal
          ZFIN
          biu1Tg; biu3Tg + MO1-slc16a2
          has condition:
          standard conditions
          • central nervous system development disrupted, abnormal
          ZFIN
          biu2Tg + MO1-slc16a2
          has condition:
          standard conditions
          • brain deformed, abnormal
          • embryo development disrupted, abnormal
          ZFIN
          biu2Tg + MO2-slc16a2
          has condition:
          standard conditions
          • brain deformed, abnormal
          • embryo development disrupted, abnormal
          ZFIN
          s843Tg + MO3-slc16a2
          has condition:
          standard conditions
          • brain vasculature malformed, abnormal
          • cranial vasculature malformed, abnormal
          ZFIN
          slc16a2biu19/biu19
          has condition:
          standard conditions
          • whole organism opn1mw2 expression decreased amount, abnormal
          • whole organism optomotor response decreased process quality, abnormal
          ZFIN
          Showing 1 - 10 of 29 rows
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          Sequence Feature Viewer

          No data available

          Sequence Details

          Transcript: Mode:

          Expression

          Primary Sources
          Other Sources
          all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          No data available

          Genetic Interactions

          No data available