Predicted to enable several functions, including activin binding activity; transforming growth factor beta binding activity; and transmembrane receptor protein serine/threonine kinase activity. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be located in membrane raft. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; head; mesoderm; and trigeminal ganglion. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2).