Gene

nkx2.2a

Species
Danio rerio
Symbol
nkx2.2a
Name
NK2 homeobox 2a
Synonyms
  • id:ibd5090
  • nk2.2
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within endocrine pancreas development; floor plate formation; and neurogenesis. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; nervous system; neural keel; neural rod; and neural tube. Orthologous to human NKX2-2 (NK2 homeobox 2).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24340
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
endocrine pancreas development disrupted, abnormal
endocrine pancreas physical object quality, abnormal
floor plate formation disrupted, abnormal
fourth ventricle increased size, abnormal
glial cell bicellular tight junction absent, abnormal
glial cell migration disrupted, abnormal
glial cell mislocalised, abnormal
heart edematous, abnormal
lateral floor plate composition, abnormal
mandibular arch skeleton decreased size, abnormal
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCz11
Viewer Help
42.211M42.212M42.213M42.214M42.215M42.216M42.217M42.218M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
sa23158allele with one associated variant
point mutation
  • stop gained
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
AB + MO4-nkx2.2a
has condition:
standard conditions
  • oligodendrocyte differentiation decreased frequency, abnormal
ZFIN
AB + MO6-nkx2.2a
has condition:
standard conditions
  • endocrine pancreas development disrupted, abnormal
  • endocrine pancreas physical object quality, abnormal
ZFIN
vu12Tg + MO4-nkx2.2a
has condition:
standard conditions
  • spinal cord oligodendrocyte cell differentiation delayed, abnormal
ZFIN
vu17Tg; vu19Tg + MO4-nkx2.2a
has condition:
standard conditions
  • spinal cord has extra parts of type oligodendrocyte, abnormal
  • spinal cord has fewer parts of type oligodendrocyte, abnormal
ZFIN
vu17Tg; vu19Tg + MO4-nkx2.2a (AB)
has condition:
standard conditions
  • glial cell bicellular tight junction absent, abnormal
  • glial cell migration disrupted, abnormal
ZFIN
vu17Tg; vu234Tg + MO4-nkx2.2a (AB)
has condition:
standard conditions
  • Schwann cell development disrupted, abnormal
  • myelinating Schwann cell mislocalised, abnormal
ZFIN
vu234Tg + MO4-nkx2.2a
has condition:
standard conditions
  • spinal cord oligodendrocyte cell differentiation delayed, abnormal
  • spinal cord oligodendrocyte cell fate specification process quality, abnormal
ZFIN
WT + MO1-nkx2.2a
has condition:
standard conditions
  • floor plate formation disrupted, abnormal
  • lateral floor plate composition, abnormal
ZFIN
WT + MO1-nkx2.9 + MO2-nkx2.2b + MO4-nkx2.2a
has condition:
standard conditions
  • lateral floor plate GABAergic neuron absent, abnormal
  • lateral floor plate Kolmer-Agduhr neuron cellular quality, abnormal
ZFIN
WT + MO1-nkx2.9 + MO4-nkx2.2a
has condition:
standard conditions
  • spinal cord interneuron cellular quality, abnormal
  • ventral spinal cord interneuron differentiation disrupted, abnormal
ZFIN
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Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
42.211M42.212M42.213M42.214M42.215M42.216M42.217M42.218M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

nkx2.2a role
nkx2.2a genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
enhancer gene
nkx2.9Danio rerio
enhanced gene
phenotypic enhancement (sensu BioGRID)
PMID:20610488
enhanced gene
nkx2.2bDanio rerio
enhancer gene
phenotypic enhancement (sensu BioGRID)
PMID:20610488
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