Orc6::Hsap\ORC6^{HDK23E.Orc6.UAS.GFP}

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Species

Drosophila melanogaster

Symbol

Orc6::Hsap\ORC6^{HDK23E.Orc6.UAS.GFP}

Category

allele

Allele of gene

None

Transgenic Constructs

• P{Orc6-UAS-HDK23E.N-GFP}

Synonyms

• Orc6::Hsap\ORC6[HDK23E.Orc6.UAS.GFP]

Description

The native Orc6 promoter and UASt regulatory sequences are fused upstream of a hybrid protein composed of the N-terminal 206 amino acids of Hsap\ORC6 fused to the C-terminal 52 amino acids of Orc6. The protein contains a K23E amino acid substitution, a variant identified in a patient with Meier-Gorlin syndrome. The coding sequence is tagged at the N-terminal end with GFP.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations