Version: 8.0.0
Date: Tue Jan 28 2025
Apc2sgRNA.UAS
FB:FBal0374045Drosophila melanogaster
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Apc2sgRNA.UAS

Species
Drosophila melanogaster
Symbol
Apc2sgRNA.UAS
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Apc2[sgRNA.UAS]
Description
UAS regulates expression of a sequence containing sgRNAs targeting Apc, Apc2, p53, Med, Pten and cic, which are the orthologs of the most frequently mutated tumor suppressors in colorectal cancer patients. Each sgRNA is flanked by tRNA sequences. Note that a knockout of cic could not be verified.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
P{UAS-Apc,Apc2,p53,Med,Pten,cic.sgRNA}
Expressed Components
None
Knock-down Targets
Regulatory Regions
  • UAS
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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