Version: 8.0.0
Date: Tue Jan 28 2025
Mmus\JunUAS.KTR
FB:FBal0399642Drosophila melanogaster
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Mmus\JunUAS.KTR

Species
Drosophila melanogaster
Symbol
Mmus\JunUAS.KTR
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Mmus\Jun[UAS.KTR]
Description
UASt sequences regulate expression of the 'JNK-KTR' kinase translocation reporter of JNK activity (PMID:24949979). 'JNK-KTR' is a fusion protein composed of a JNK docking site from Mmus\Jun, a suboptimal bipartite nuclear localization signal (bNLS), a nuclear export signal (NES) and the Clover fluorescent protein. Both the bNLS and NES have been mutated to contain consensus phosphorylation sites for JNK, such that phosphorylation decreases the activity of the bNLS and increases the activity of the NES. This results in the protein shuttling from the nucleus to the cytoplasm in response to JNK phosphorylation.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
M{UAS-JNK-KTR}
Expressed Components
Knock-down Targets
None
Regulatory Regions
  • UASt
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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