Lepr^db-3J

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Species

Mus musculus

Symbol

Lepr^db-3J

Category

allele

Allele of gene

Lepr

Transgenic Constructs

None

Synonyms

None

Description

Sequence analysis of the 3J allele revealed a 17 nucleotide deletion beginning at base 1874. This deletion results in a shift of the reading frame, and a premature termination of the protein at the 11th amino acid after the deletion site. The mutation is predicted to result in a truncated receptor without a transmembrane domain and affects all Lepr splice variants.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations