Dct^Slt-lt

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Species

Mus musculus

Symbol

Dct^Slt-lt

Category

allele

Allele of gene

Dct

Transgenic Constructs

None

Synonyms

None

Description

The mutation has been identified as an G-to-A transition (C-to-T on forward strand) at coding nucleotide position 1456 in exon 8, that results in replacement of glycine with arginine at amino acid position 486 (p.G486R), in the predicted transmembrane domain of the protein. The mutation does not prevent membrane insertion, but it shifts the entire transmembrane region approximately four amino acids toward the N-terminus.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations