Ldlr^tm1Her

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Species

Mus musculus

Symbol

Ldlr^tm1Her

Category

allele

Allele of gene

Ldlr

Transgenic Constructs

None

Synonyms

• LDLR KO
• LDLR-

Show All 7

Description

Insertion of a neomycin resistance cassette into exon 4. The authors predict that the targeted allele would encode a truncated non-functional protein that will not bind LDL, and that lacks a membrane spanning segment. Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations