Nfkb1^tm1Bal

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Species

Mus musculus

Symbol

Nfkb1^tm1Bal

Category

allele

Allele of gene

Nfkb1

Transgenic Constructs

None

Synonyms

• NF-kappaB^tm1Bal
• NF-kappaB1 KO

Show All 9

Description

Insertion of a PGK-neomycin resistance cassette into exon 6 disrupted the gene. Exon 6 encodes the p105 precursor of the p50 subunit of the encoded transcription factor. The authors predict that this allele produces a truncated polypeptide that cannot bind with DNA, or dimerize with itself or other kappaB binding motifs.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations