Version: 8.0.0
Date: Tue Jan 28 2025
Nos3tm1Unc
MGI:1857229
Allele of Nos3
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Nos3tm1Unc

Species
Mus musculus
Symbol
Nos3tm1Unc
Category
allele
Allele of gene
Nos3
Transgenic Constructs
None
Synonyms
  • ecNOS-
  • eNOS-
Description
A 1.2 kb neomycin cassette replaced 129 bp of exon 12 of the gene. This disrupted the calmodulin binding site of the protein and introduced a premature stop codon into the transcripts. Immunohistochemisty of heart and kidney sections from homozygous mutant mice confirmed that no detectable encoded protein was present.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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