Allele/Variant

Prkcgtm1Stl

Species
Mus musculus
Symbol
Prkcgtm1Stl
Category
allele
Allele of gene
Prkcg
Transgenic Constructs
None
Synonyms
  • PKCgamma-KO
Description
A neomycin resistance cassette replaced 2.5kb of sequence containing the exon that encodes the nucleotide binding domain. Northern blot analysis of total brain RNA demonstrated that homozygous mutant mice lack normal transcripts. Western blot analysis of total brain protein did not detect the protein in homozygous mutant mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal contextual conditioning behaviorMGI
abnormal excitatory postsynaptic currents
MGI
abnormal impulsive behavior controlMGI
abnormal nociception after inflammation
MGI
abnormal pain threshold
MGI
abnormal spatial learningMGI
alcohol preferenceMGI
decreased anxiety-related responseMGI
decreased inflammatory response
MGI
enhanced behavioral response to alcoholMGI
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Disease Associations

No data available