Allele/Variant

Ptgs1tm1Unc

Species
Mus musculus
Symbol
Ptgs1tm1Unc
Category
allele
Allele of gene
Ptgs1
Transgenic Constructs
None
Synonyms
  • COX-1-
  • PGHS-1-
Description
A ~1 kb genomic fragment containing intron 10, and the first 44 bp of exon 11 was replaced with a neomycin selection cassette. Northern blot analysis on colon and kidney RNA demonstrated that a 1.1 kb aberrant transcript was produced from this allele. Western blot analysis on kidney, stomach or colon tissue lysates derived from homozygous mice confirmed that no detectable protein is produced from this allele, and additional western blots on proteins derived from LPS-induced macrophages derived from homozygous mice demonstrated that no encoded protein was present.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations