Allele/Variant

Serpine1tm1Mlg

Species
Mus musculus
Symbol
Serpine1tm1Mlg
Category
allele
Allele of gene
Serpine1
Transgenic Constructs
None
Synonyms
  • PAI-1-
  • Planh1tm1
Description
A PGK-neomycin resistance cassette replaced all of the Serpine1 coding sequence and part of the promoter region including the transcription initiation site. Northern blot analysis did not detect Serpine1 mRNA in endotoxin-treated homozygous mutant liver. Neither untreated nor endotoxin-treated homozygous mutant kidney produced detectable SERPINE1 immunoreactivity. A monoclonal antibody based immunofunctional assay did not detect protein levels in plasma of endotoxin-treated homozygous mutant mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations