Sele^tm1Hyn

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Species

Mus musculus

Symbol

Sele^tm1Hyn

Category

allele

Allele of gene

Sele

Transgenic Constructs

None

Synonyms

• E-selectin^-
• Sele^-

Description

A modified D3 ES cell line heterozygous for the Selp^tm1Hyn allele was targeted a second time. The exons encoding the signal peptide, lectin domain, and a portion of the epidermal growth factor domain were replaced by the insertion of a PGK-hygro cassette. Both Northern and RT-PCR analysis revealed an absence of normal message for both genes in extracts from cardiac and pulmonary tissue of homozygous mutant mice. This targeted mutation occurred in cis with the Selp^tm1Hyn mutation. Due to their genomic proximity, the two null alleles should propagate together through the offspring.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations