Rac2^tm1Mddw

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Species

Mus musculus

Symbol

Rac2^tm1Mddw

Category

allele

Allele of gene

Rac2

Transgenic Constructs

None

Synonyms

• rac2-
• Rac2^tm1Daw

Description

A neomycin resistance cassette replaced a genomic fragment containing exon 1, which encodes the translational initiation site and part of the GTP-binding domain. Northern blot and RT-PCR analysis demonstrated that no transcripts were detectable in total RNA derived from neutrophils or lymphocytes in homozygous mice. Western blot analysis confirmed an absence of protein produced from this allele in peritoneal exudate cells from homozygous mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations