Allele/Variant

Rac2tm1Mddw

Species
Mus musculus
Symbol
Rac2tm1Mddw
Category
allele
Allele of gene
Rac2
Transgenic Constructs
None
Synonyms
  • rac2-
  • Rac2tm1Daw
Description
A neomycin resistance cassette replaced a genomic fragment containing exon 1, which encodes the translational initiation site and part of the GTP-binding domain. Northern blot and RT-PCR analysis demonstrated that no transcripts were detectable in total RNA derived from neutrophils or lymphocytes in homozygous mice. Western blot analysis confirmed an absence of protein produced from this allele in peritoneal exudate cells from homozygous mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations