Allele/Variant

Map2k3tm1Flv

Species
Mus musculus
Symbol
Map2k3tm1Flv
Category
allele
Allele of gene
Map2k3
Transgenic Constructs
None
Synonyms
  • MKK3 KO
  • Mkk3-
Description
A neomycin resistance cassette replaced a 1.5kb region that includes exons 8 and 9, which encode amino acids 217-221 of the protein. This region includes the sequences containing the dual phosphorylation sites (serine and threonine) that are required for activation of the protein. Northern blot and Western blot analyses did not detect expression from this allele in homozygous mutant mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations