Edar^Tg(OVE1B)Ove

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Species

Mus musculus

Symbol

Edar^Tg(OVE1B)Ove

Category

allele

Allele of gene

Edar

Transgenic Constructs

None

Synonyms

• Edar^{TgN(OVE1B)Ove}
• OVE 1B

Description

A transgene containing a hybrid DNA construct, which includes the regulatory sequences of the mouse alpha-crystallin gene and the early region of SV40, inserted into the gene. A founder mouse from one microinjection event produced offspring carrying two different integration sites. The subsequent lines were called Edar^{TgN(OVE1A)Ove} and Edar^{TgN(OVE1B)Ove}. In both cases, integration was accompanied by a genomic deletion and an intrachromosomal inversion. The deletions were found to be overlapping. This allele is defined by a noncomplementation test with Edar^dl, and contains a 600 kb deletion.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations