Pitx2^tm2Sac

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Species

Mus musculus

Symbol

Pitx2^tm2Sac

Category

allele

Allele of gene

Pitx2

Transgenic Constructs

None

Synonyms

• Pitx2^-
• Pitx2^null

Description

This allele is derived from Pitx2^tm1Sac. Gene targeting was performed with a vector engineered to contain a loxP site downstream from exon 4 and a floxed neomycin cassette upstream of exon 4. Subsequent cre expression resulted in deletion of both the neo selection cassette and exon 4. This allele is a demonstrated to be a functional null.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations