Allele/Variant

Parp1tm1Zqw

Species
Mus musculus
Symbol
Parp1tm1Zqw
Category
allele
Allele of gene
Parp1
Transgenic Constructs
None
Synonyms
  • ADPRT-
  • Adprt1tm1Wag
Description
A promoterless neomycin gene replaced part of exon 2 and intron 2. The neomycin sequences were fused in-frame to the coding sequence of the gene. Northern blot analysis detected a truncated fusion transcript in homozygous mice. Enzyme activity assays demonstrated a lack of functional ADPRT1 protein in homozygous mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations