Version: 8.0.0
Date: Tue Jan 28 2025
Vdrtm1Ska
MGI:1859929
Allele of Vdr
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Vdrtm1Ska

Species
Mus musculus
Symbol
Vdrtm1Ska
Category
allele
Allele of gene
Vdr
Transgenic Constructs
None
Synonyms
  • Tokyo VDR-KO
  • Vdr KO
Description
A neomycin resistance gene cassette replaced 1.1kb of sequence containing exon 2, which encodes the first zinc finger of the DNA binding domain. RT-PCR and Western blot analysis of intestinal tissue from homozygous mice detected the presence of a truncated transcript and protein that appears to use M53 in exon 3 as an initiation site. This truncated protein is able to bind ligand but lacks transactivation activity.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
    References
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page