Igf1^tm2Ts

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Species

Mus musculus

Symbol

Igf1^tm2Ts

Category

allele

Allele of gene

Igf1

Transgenic Constructs

None

Synonyms

• IGF-I^m
• Midi allele

Description

Hypomorph. In this allele, a site specific insertion of the entire targeting vector occurred instead of homologous recombination. The construct interrupted exon 3 with a neomycin cassette, with a thymidine kinase gene and vector sequences inserted 5' of the endogenous exon 3. RT-PCR analysis demonstrated that a reduced amount of normal transcript was produced from this allele as well as a mutant transcript, and a low, but detectable level of the protein was present in sera of homozygous mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations