Allele/Variant

Numbtm1.1Ynj

Species
Mus musculus
Symbol
Numbtm1.1Ynj
Category
allele
Allele of gene
Numb
Transgenic Constructs
None
Synonyms
  • m-numb(delta 5,6)
Description
Mice homozygous for the Numbtm1Ynj allele were mated with transgenic mice which express Cre recombinase under the control of the beta-actin promoter. The presence of Cre resulted in germline deletion of sequences in exons 5 and 6 of the Numb gene that encode the middle portion of the phosphotyrosine binding domain of the protein. C terminus immunoreactivity was not detected in protein extracts from homozygous mutant 10.5 day embryos.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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