Ercc6^tm1Gvh

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Species

Mus musculus

Symbol

Ercc6^tm1Gvh

Category

allele

Allele of gene

Ercc6

Transgenic Constructs

None

Synonyms

• CSB-
• Csb^-

Show All 3

Description

Insertion of a floxed neomycin resistance cassette into exon 5 near a site corresponding to a known human mutation disrupted the Ercc6 gene. RT-PCR and Western blot analyses of E13.5 fibroblasts from homozygous mutant animals did not detect wild-type transcript or wild-type protein, but indicate that the mutant allele expresses mRNA at low levels.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations