Allele/Variant

Notch2tm1Grid

Species
Mus musculus
Symbol
Notch2tm1Grid
Category
allele
Allele of gene
Notch2
Transgenic Constructs
None
Synonyms
  • Notch2-
  • Notch2del1
Description
This is a hypomorphic allele. A neomycin resistance cassette replaced 0.4 kb of sequence, including part of the exon encoding EGF repeat 14, the splice donor site at the 3' end of this exon, and 0.3 kb of intron. mRNA species are detected in homozygous mutant embryos that appear to be the result of inframe splicing around the neomycin cassette. Proteins derived from these transcripts are predicted to have a deletion of one or two EGF repeats.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations