Allele/Variant

Pou5f1tm1Cgre

Species
Mus musculus
Symbol
Pou5f1tm1Cgre
Category
allele
Allele of gene
Pou5f1
Transgenic Constructs
None
Synonyms
  • Oct4-
Description
An internal ribosome entry site-lacZ-neomycin resistance cassette (IRES-beta-geo) replaced sequences in exons 2-5 encoding the two DNA binding domains and the carboxy terminal transactivation site. Immunostaining did not detect wild-type protein in 3 of 15 2.5 day morulae from an intercross of heterozygous mutant animals.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
absent inner cell massMGI
embryonic lethality between implantation and somite formation, complete penetranceMGI
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Disease Associations

No data available