Flt1^tm1Msh

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Species

Mus musculus

Symbol

Flt1^tm1Msh

Category

allele

Allele of gene

Flt1

Transgenic Constructs

None

Synonyms

• flt tk^-
• Flt-1^TK-

Show All 3

Description

A PGK-neomycin resistance cassette replaced exon 17, which encodes the amino terminal region of the tyrosine kinase domain. Northern blot analysis of homozygous mutant embryos using a 5' cDNA probe detected a ~3kb mRNA, and detected no 7kb full length transcript using a 3' probe. Immunoblot analysis of lung tissue from homozygous mutant mice detected the endogenous soluble form of the protein, and a novel truncated form that lacks the cytoplasmic region. No full length protein was expressed from this allele.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations