Fcer2a^tm1Putt

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Species

Mus musculus

Symbol

Fcer2a^tm1Putt

Category

allele

Allele of gene

Fcer2a

Transgenic Constructs

None

Synonyms

• CD23-

Description

A neomycin resistance cassette replaced 800 bp of the gene including part of exon 10, all of exon 11, and part of exon 12. The deleted sequences encode the carboxy-terminus, including the lectin homology domain with sequences that bind the C epsilon domain of IgE. Northern blot analysis of spleen did not detect transcript in homozygous mutant mice. Flow cytometric analysis did not detect protein on the surface of splenic B cells in homozygous mutant mice. Immunocytochemical analysis did not detect protein in asteroid dentritic cells near the corticomedullary junction of homozygous mutant thymus.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations